Selective serotonin reuptake inhibitors, or SSRIs, are newer antidepressants that often treat the symptoms of depression more effectively than TCAs and for many people, produce less troublesome side effects.
SSRIs include:
Zoloft (sertraline)
Paxil (paroxetine)
Celexa (citalopram hydrobromide)
Prozac (fluoxetine)
Effexor (venlafaxine)
Luvox (fluvoxamine maleate)
Besides treating depression, SSRIs are sometimes used to treat the symptoms of obsessive-compulsive disorder. Luvox in particular is thought to help patients control their obsessions and compulsions.
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Zoloft (sertraline)
Zoloft is used to treat
How it works - Zoloft is a SSRI that works by restoring levels of the neurotransmitter serotonin, thereby relieving depression symptoms.
Possible side effects of Zoloft
The following list may not contain all of the side effects associated with this medication:
Most common side effects
Infrequent side effects
Rare side effects/Risks
Before you begin this medication, consult your doctor
If you have kidney or liver disease.
If you are on another antidepressant agent.
If you have a history of seizures.
If you suffer from mania or have suicidal thoughts.
Possible drug interactions
Zoloft may increase the effects of:
Valium(diazepam)
Orinase(tolbutamide)
Coumadin(warfarin)
Tagamet (cimetidine) may induce Zoloft toxicity
Tambocor (flecainide) may lead to flecainide toxcititiy.
Norvir (ritonavir) may also lead toxicity.
Antidiabetic drugs taken with Zoloft may increase the risk of hypoglycemic reactions.
Avoid alcohol when taking Zoloft; it is advised in depressed patients to avoid alcohol due to potential adverse reactions.
Overdose
Symptoms of overdose include nausea, vomiting, drowsiness, hyperactivity, and enlarged pupils.
If you think you may have taken an overdose of Zoloft, go to the emergency room or seek other medical attention immediately!
Storage
This drug should be kept in a cool dry area, away from extreme heat or moisture.
Other important information
If you are pregnant, plan to become pregnant, or breastfeeding, discuss the potential risks of this or any medication with your doctor.
Therapy with this agent may increase triglycerides and other lab tests.
Reminders
Keep this and all other medications out of the reach of children
Never share medications with others
Only use this medication as your doctor has prescribed.
Paxil (paroxetine)
Paxil is used to treat
How it works - Paxil is a SSRI that works by restoring levels of the neurotransmitter serotonin, thereby relieving depression symptoms.
Possible side effects of Paxil
The following list may not contain all of the side effects associated with this medication:
Most common side effects
Infrequent side effects
Rare side effects/Risks
Before you begin this medication, consult your doctor
If you have had a history of seizure disorders.
If you have thoughts of death or suicide.
If you have kidney or liver disease.If you have a history of drug abuse.
If you have a history of mania or bipolar disorder.
Possible drug interactions
Paxil may increase the effects of:
Benzodiazepine
Desipramine
Haldol(haloperidol)
Normodyne(labetalol)
Other possible drug interactions
Dilantin (phenytonin) may result in a decrease of Paxil in the blood thus reducing its effects.
Quinaglute (quinidine) and Tagamet (cimetidine) may increase Paxil levels and may induce toxicity.
Ultram (tramadol) may lead to a risk of seizures.
Tryptophan may result in sweating, nausea, and dizziness when combined with Paxil.
Coumadin ( warfarin) may result in bleeding when taken with Paxil.
Alcohol has not been shown to increase cognitive or motor skills when taken with Paxil; however, alcohol is advised to be avoided when taking Paxil.
Overdose
Symptoms of overdose include nausea, vomiting, tremor, seizure, drowsiness, hyperactivity, and enlarged pupils.
If you think you may have taken an overdose of Paxil, go to the emergency room or seek other medical attention immediately!
Storage
This medication should be kept in a cool dry area, away from extreme heat or moisture.
Other important information
If you are pregnant, plan to become pregnant, or breastfeeding, discuss the potential risks of this or any medication with your doctor.
Paxil levels in elderly patients may be higher than younger ones and may have to be decreased accordingly but no significant difference was found between young and older patients.
Paxil may cause excessive sweating and patients should drink a lot of water or other non-alcoholc beverages when taking this medication.
Reminders
Keep this and all other medications out of the reach of children
Never share your medications with others
Only use this medication as your doctor has prescribed
Celexa (citalopram hydrobromide)
Celexa is used to treat
Depression
Obsessive-Compulsive Disorder (NOT an FDA-approved indication)
How it works - Celexa restores levels of the neurotransmitter serotonin, thereby relieving depression and other related disorders.
Possible side effects of Celexa
The following list may not contain all of the side effects associated with this medication:
Most common side effects
nausea
dry mouth
sleepiness
increase in sweating
low blood pressure
decrease in weight/increased weight
increased appetite
impaired concentration
Infrequent side effects
high blood pressure
hot flashes
dry eyes
arthritis
muscle weakness
Rare side effects/Risks
hyponatremia (low concentration of sodium in blood that often occurs in dehydration)
sexual difficulties (decreased libido
ejaculation disorder and impotence)
Before you begin this medication, consult your doctor
If you have any other medical problems.
If you have kidney or liver problems.
If you have a history of seizures.
If you have a history of drug abuse.
If you have a history of mood disorders, such as mania, or thoughts of suicide.
If you are allergic to medications, foods, or other substances.
Possible drug Interactions
Overdose
Symptoms of overdose include nausea, vomiting, dizziness, sweating, and rapid heartbeat.
If you think you may have taken an overdose of Celexa, go to the emergency room or seek other medical attention immediately!
Storage
This medication should be stored in a cool dry area away from extreme heat or moisture.
Other Important Information
If you are pregnant, plan to become pregnant, or breastfeeding, discuss the potential risks of this or any medication with your doctor.
Older patients may be more sensitive to Celexa than younger patients, and thus may require a lower dosage.
Reminders
Keep this and all other medications out of the reach of children
Never share your medications with others
Only use this medication only as your doctor has prescribed
Prozac (fluoxetine)
Prozac is used to treat
How it works - Prozac is a SSRI that works by restoring levels of the neurotransmitter serotonin, thereby relieving depression symptoms.
Possible side effects of Prozac
The following list may not contain all of the side effects associated with this medication:
Most common side effects
decreased appetite
weight loss
nausea
altered taste
insomnia
headache
Infrequent side effects
blurred vision
anxiety
nervousness
drowsiness
dizziness
excessive sweating
anorexia
impaired erection
Rare side effects / Risks
hypomania
seizures
tremor
Before taking this medication, consult your doctor
If you have a history of seizure disorder.
If you have severe kidney or liver disease.
Possible drug interactions
Prozac may increase the effects of:
Valium(diazepam)
Digitoxin/digoxin(digitalis preparations)
Dilantin(phenytoin)
Coumadin(warfarin)
Prozac increases levels of:
Clozaril (clozapine)
Haldol (haloperidol)
Claritin (loratadine)
Dextromethorphan (cough suppressant) and Toradol (ketorolac) may result in hallucinations when taken with Prozac.
Lithium, tryptophan, and Eldepryl (selegiline) may result in drug toxicity.
Ultram (tramadol) may increase seizure risk.
Overdose
Symptoms of overdose include sedation, coma, agitation, violent vomiting, and respiratory depression.
If you think you may have taken an overdose of Prozac, go to the emergency room or seek other medical attention immediately!
Storage
This medication should be kept in a cool, dry area, away from extreme heat or moisture.
Other important information
If you are pregnant, plan to become pregnant, or breastfeeding, discuss the potential risks of this or any medication with your doctor.
Avoid grapefruit juice when taking Prozac due to the increased blood levels of the drug.
Reminders
Keep this medication out of the reach of children
Never share your medications with others
Only use this medication as your doctor has prescribed.
Effexor (venlafaxine)
Effexor is used to treat:
How it works - Effexor increases the levels of the neurotransmitters serotonin and norepinephrine.
Possible side effects of Effexor
The following list may not contain all of the side effects associated with this medication:
Most common side effects
headache
insomnia
dizziness
abnormal ejaculation
weakness
neck pain
nausea
weight loss
fast heart beat
increased blood pressure
unusual tiredness
constipation
Infrequent side effects
anxiety/nervousness
blurred vision
diarrhea
dizziness
dry mouth
insomnia
sexual difficulties
difficulty swallowing
Rare side effects/Risks
hypomania
increased blood pressure
seizures
lightheadedness
changes in taste
ringing in ears
mood or behavior changes
ear pain
Before taking this medication, consult your doctor
If you have high blood pressure.
If you have a history of seizures.
If you have heart, liver, or kidney disease.
If you have thoughts about suicide.
If you are allergic to other medications.
Possible drug interactions
Overdose
Symptoms of overdose include seizures, rapid heart beat, drowsiness, and confusion. Other symptoms may occur.
If you think you may have taken an overdose of Effexor, go to the emergency room or seek other medical attention immediately!
Storage
Keep this and other drugs in a cool dry area away from extreme heat or moisture.
Other important information
If you are pregnant, plan to become pregnant, or breastfeeding, discuss the potential risks of this or any medication with your doctor.
There seems to be no adverse interactions with alcohol, but due to the possibly adverse effects alcohol may have on a depressed individual, it should be avoided.
Don't discontinue using this drug without consulting your doctor.
Reminders
Keep this and other medications out of the reach of children
Never share medications with others
Only use this medication as your doctor has prescribed
Luvox (fluvoxamine)
Luvox is used to treat
Obsessive Compulsive Disorder
Depression
Panic Attacks
How it works - Luvox works by balancing the levels of a neurotransmitter, serotonin, thereby relieving the symptoms of OCD and depression.
Possible side effects of Luvox
The following list may not contain all of the side effects associated with this medication:
Most common side effects
dry mouth
constipation
anorexia
nausea
insomnia
drowsiness
Infrequent side effects
dizziness
headache
agitation
sleep disorders
delayed or absent orgasm
diarrhea
weakness/loss of strength
Rare side effects/Risks
hypomania
liver toxicity
Before taking this medication, consult your doctor
If you have a seizure disorder, heart, kidney, or liver disease.
If you have had a history of drug dependence or abuse.
If you have had a history of mood disorders or thoughts of suicide.
If you are allergic to any other medication, food or other substance.
Possible Drug Interactions
DO NOT take Luvox when taking
Seldane (terfenadine), or
Hismanal (astemizole)
due to the possible serious heart arrhythmias that may occur when these medications are taken together.
The following medications when taken with Luvox may lead to drug toxicity
Luvox stays in the body up to one-quarter less the time in nonsmokers than smokers.
Marijuana smoking may add to the drowsiness effect of Luvox.
Overdose
Symptoms of overdose include nausea, vomiting, dizziness, hyperactivity, slow heartbeat, tremors, abdominal pain, and seizures.
If you think you may have taken an overdose of Luvox, go to the emergency room or seek other medical attention immediately!
Storage
This medication should be stored in a cool dry area, away from extreme heat and moisture.
Other important information
If you are pregnant, plan to become pregnant, or breastfeeding, discuss the potential risks of this or any medication with your doctor.
If nausea and vomiting continue for more than two days after you start taking this medication, call your doctor.
A withdrawal syndrome has been reported if this medication is stopped suddenly so do not stop taking this drug without first talking to your doctor.
Reminders
Keep this and all other medications away from children
Never share your medications with others
Only use this medication as your doctor prescribed
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